The Centre de'Etude du Polymorphism Humain (CEPH), Foundation Jean Dausset in Paris, France, transferred lymphoblastoid cell lines (LCLs) from its collection of 61 reference families to the NIGMS Repository. The samples are available as LCLs and DNA samples. Family relationships were verified at Coriell and approved by CEPH. Additional data regarding these samples are available on the CEPH website: http://www.cephb.fr/.
STATEMENT TO USERS OF CEPH REFERENCE FAMILIES
The Centre d"Etude du Polymorphisme Humain (CEPH), Foundation Jean Dausset, Paris, France
has contributed its collection of 61 reference families to the Repository. The CEPH collection
includes families collected by R. White (Utah), J. Dausset (French), J. Gusella (Venezuelan), and
J. Egeland (Amish). There are a total of 809 individuals accounting for 832 pedigree positions in
the reference families.
This panel of reference families is an important resource for the characterization of DNA
polymorphisms, the construction of the human genetic map, and other research efforts where
access to a common reference data set is of value.
The most efficient approach to constructing genetic maps of all the chromosomes is to type the
same set of families and to contribute the genotypes to and use a database in which these data
accumulate. This is the basis for the CEPH international collaboration to genetically map the
human genome. One hundred and three collaborating laboratories in the U.S.A., Canada,
Europe, South Africa, Australia and Japan genotype DNA from the reference families and send
the data to CEPH where they are merged into a database which is available to all collaborators
for the construction of genetic maps. Several maps of the human genome have been published
based on the genotypes from CEPH reference families, the most recent by the NIH/CEPH
Collaborative Mapping Group (Science 258, 67-86, 1992) and by Weissenbach et al. (Nature
359, 794-801, 1992).
CEPH and the NIGMS Repository strongly recommend that investigators
utilizing the extended family collection of LCLs contribute their genotypic data to CEPH for
inclusion in the database. CEPH will provide the database to all those who contribute genotypes.
Further information on collaboration with CEPH can be obtained by contacting:
CEPH at Foundation Jean Dausset
Samples from these families were also used for the International HapMap Project (HapMap Project; for samples see HapMap Samples).
Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JM, and White R. Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome.
Genomics 6:575-7 (1990).
Cann HM. CEPH maps. Curr Opin Genet Dev. 2:393-9 (1992)
CEPH Family Kits
CEPH DNA Pools