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Chromosome 21
Records Return:  (12)

Catalog IDPercent of Cells
with Chromosome
Cytogenetic DescriptionAdditional Information
GM11980100der(1)t(1;21)(p31;q22) (100%) & other human chromosomesLine 1881C-13b; human fibro, GM01881, 46,XY,t(1;21)(p31;q22), fused with Chinese hamster ovary K1 mutant Ade C cells; grown in hypoxanthine-free medium with 7% dialyzed FBS; retains der(1) in 100% of cells & other human chromosomes
GM14065100der(21)t(8;21)(q22.1;q22.3) (100%)Line 21q+; produced by the fusion of human cells, t(8;21)(q22.1;q22.3), from an AML-M2 pt with Chinese hamster ovary Gly-B cells; grown in glycine-free HF12D medium with proline & 5% dialyzed FBS; retains hum der(21)t(8;21) in ??% cells
GM1006398der(X)t(X;21)(p21;p12) (98%)Line A2-4; HPRT-deficient mouse A9 cells fused with fibroblasts from a patient, GM10062, t(X;21)(p21;p12), with muscular dystrophy; grown in HAT medium; 98% of cells retain the human der(X) chromosome
GM1175296der(3)t(3;21)(p24.2;q21) (96%)Line 3;21/UC2-1; produced by the fusion of human lymphoblasts, GM09528, t(3;21) (p24.2;q21), with CHO Q131-91A cells; grown in uridine-def F12 medium with 5% dialyzed FBS; retains der(3)t(3;21) in 96% of cells
GM1197996der(4)t(4;21)(p16.3;q11.2) (96%) & other human chromosomesLine GA9-3; human fibroblasts, GM08210, 45,XX,-4,-21,+t(4;21)(p16.3;q11.2) fused with CHO K1 mutant Ade A cells; grown in hypoxanthine-free HF12 medium with 7% dialyzed FBS; retains der(4)t(4;21) in 96% of cells & other human chromosomes
GM1406496der(8)t(8;21)(q22.1;q22.3) (96%)Line 8q-a; produced by the fusion of human cells, t(8;21)(q22.1;q22.3), from an AML-M2 patient with Chinese hamster ovary Ade-C cells; grown in HF12 medium with hypoxanthine; retains human der(8) t(8;21) in ??% of cells
GM1441696der(6)t(6;21)(p25;q11) (96%) & add(3)(p?) (96%) & 12 (96%) & X (92%)Line R50-3; produced by the fusion of GM00144, 45,XX,-6,-21,+der(6)t(6;21), with pyrimidine auxotrophic CHO line, J405; selected and grown in purine-free medium; retains hum der(6)t(6;21) (96%), add(3)(p?) (96%), #12 (96%), & X (92%)
GM1197892der(21)t(10;21)(q24.1;q22.1) (92%)Line 9542C-5a; fusion of human lymphos, GM09542, 46,XY,t(10;21)(10pter>10q24.1:: 21q22.1>21qter;21pter>21q22.1::10q24.1> 10qter), & Chinese hamster ovary-K1 purine auxotrophic mutant AdeC cells; grown in hypoxanthine-free HF12 med & 5% dialyzed FBS; der(21)t(10;21)(q24.1;q22.1) in 92% of cells
GM1422792der(18)t(18;21)(p11.1;q11.2) (92%)Line HHW778; produced by the fusion of human cells with Chinese hamster UCW206 cells, GM14228; grown in medium with 0.2mM proline at 39C; retains a human der(18)t(18;21)(p11;q11.2) in 92% of cells
GM1441588der(21)t(21;22)(q22.3;q11) (88%) & other human chromosomesLine Raj5; produced by fusion of myelocytes from a CML pt, 46,XX,t(21;22)(q22; q11), with purine auxotrophic mutant CHO line, Ade-C; selected & grown in purinefree medium; retains hum der(21)t(21;22) (q22.3;q11) in 88% of cells
GM0914286 Line C2-T10; HPRT-deficient A9 mouse cells fused with human fibroblasts, t(X;21)(p21;p12); 86% of cells retain the der(21), 100% have human chromosome #3, & 50% of cells have human chromosome #5
GM1113060der(21)t(1;21)(p22;q21.2) (60%) & other human chromosomesLine AHVI-17; produced by fusing fibroblasts, GM01881, 46,XY,t(1;21)(p31;q22) with HPRT-deficient mouse line A9; retains human der(21)t(1;21)(p22;q21.2) & human chromosomes #2, 18, & X in 60%, 66%, 56%, & 9O% of cells respectively

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